STRESS AND AVOIDANCE
Our lab explores hippocampal mechanisms underlying avoidance behavior in rodents, which may reflect aspects of anxiety in humans. We study how these mechanisms differ in males and females, as well as after early life adversity. Using a variety of behavioral, molecular, cellular, biochemical, and electrophysiological methods, we are studying the role of neurosteroids, new neurons, interneurons, perineuronal nets, and microglia in modulating the neuronal circuitry underlying the regulation of avoidance behavior.
Our lab investigates hippocampal mechanisms of social novelty preference and recognition. We study how social behavior develops and is maintained in healthy and impaired mice, using early life adversity and transgenic models. Using chemogenetics, in vivo electrophysiology, behavioral analysis, and high-resolution imaging approaches, we explore the microcircuits and cells underlying these important functions.